US-27 enters Florida from Georgia a few miles north of Havana. It continues south along an easterly and southerly path for 496 miles until it gets to Miami. It was a major highway before the Turnpike and interstates.
The highway travels for much of its length along the central ridge of Florida. This is some of the highest ground in the state. It goes through many historic areas you would never see if you stay on the Turnpike or I-75.