Melrose is a quiet unincorporated village about 19 miles east of Gainesville at the intersection of State Roads 26 and 21. An unusual thing about Melrose is its location in four counties: Alachua, Bradford, Clay, and Putnam.
The rustic streets, many of them unpaved, are canopied by ancient oaks draped with Spanish moss. There are 72 well preserved buildings listed in the Melrose Historic District.
